Analytical

Major analytical techniques used in research & development, quality control and quality assurance are HPLC chromatography and NMR spectroscopy. Zeochem offers silica gel packing materials for various types of chromatography and deuterated substances for the NMR spectroscopy.

Liquid Chromatography is the most important tool in any chemical analytic. Silica gel is considered the best-performing stationary phase in chromatographic separations. The various types of chromatographic techniques in use require different types of silica gels. Our wide range of silica gels meets these requirements: ZEOprep irregular shaped silica, ZEObeads spheroidal silica and ZEOsphere spherical silica. These forms are available as both bonded and unbonded silica.

Zeochem ZEOprep irregular silica and the spheroidal ZEObeads products are very reliable packing materials for analytical laboratory kits, SPEs and QuEChERS.

Zeochem's ZEOsphere materials analytical HPLC phases/columns are used in early development and discovery stages of biopharmaceutical, nutraceutical and food companies, as well as in medical and research laboratories. Analytical stationary phases for ZEOsphere silica are superb in performance. Separation methods can be developed and directly transferred to the preparatory phase via easy scale-up principles.

For analytical separations, we offer ZEOsphere Classical silica (e.g., C18, C8, C4, etc.) for any reversed phase application and ZEOsphere DRP Mixed-Mode stationary phases for charged molecules like peptides, insulins (analogues) and oligonucleotides. These products are available in analytical, semi-preparative columns or in small bulk quantities.

Standard ZEOsphere stationary phases are available in pore sizes 100Å, 120Å, 200Å, 300Å and 1000Å and in analytical particle sizes 3µm for standard HPLC or UHPLC applications (only for ZEOsphere DRP) or 5µm (for ZEOsphere Classic).

Scaling up is easier when using an HPLC media that provides nearly identical performance across all particle sizes and with increases in column diameter. Any mobile phase conditions developed on a ZEOsphere analytical column can be easily transferred to a 10 μm or 15 μm preparative column with an equivalent resolution, selectivity and proportional mass loading.



Applications

Quality Control

Classical ZEOsphere silica and ZEOsphere DRP Mixed-Mode analytical HPLC phases/columns provide excellent performance and reliable and robust solutions for your quality control activities.

Quality control is an essential operation of the biopharmaceutical, nutraceutical and other industries. For example, biopharmaceutical drugs must be marketed as safe and therapeutically active formulations with consistent and predictable performance.

New pharmaceutical grade compounds are being synthesized at an accelerated rate, and in response, more advanced and robust analytical methods are being developed for the evaluation of new drug substances and drug products. HPLC and LC-MS are playing an important and critical role as a quality control analytical method for qualitative and quantitative analysis.

The importance of HPLC or LC-MS used in biopharmaceutical industries is falling under the stringent regulations established by the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA) and other regulatory agencies. This type of regulation requires biopharmaceutical companies to test the quality of their products using either HPLC or LC-MS before they can be sold to the global market.

Our innovations in phase technology led to a selectivity revolution. ZEOsphere DRP Mixed-Mode in attraction-repulsion mode offers enhanced selectivities, making your quality control less stressful.

ZEOsphere DRP Mixed-Mode materials can contribute to achieving higher throughput, lower costs and faster time to market for routine analysis of NCEs or generic drugs.

Identification

Our ZEOsphere analytical HPLC phases/analytical columns are excellent choices for identification and quantification applications in your quality control or scientific laboratory.

Zeochem's standard ZEOsphere stationary phases are available in pore sizes 100Å, 120Å, 200Å, 300Å and 1000Å and in analytical particle sizes 3µm for standard HPLC or UHPLC applications (only for ZEOsphere DRP) or 5µm (for ZEOsphere Classic).

For standard identification/quantification application, we offer ZEOsphere Classical C18, C8, C4, Si, CN, NH2, DIOL, Phenyl, Phenyl-Hexyl and Phenyl-Butyl phases. For charged molecules like peptides, insulins (analogues) and oligonucleotides, we recommend our ZEOsphere DRP Mixed-Mode stationary phases. ZEOsphere DRP Mixed-Mode phases are available as RP/SAX and RP/SCX.

NMR Spectroscopy

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy, involves the technique of observing magnetic fields around the nuclei. Deuterium Labeled Compounds are used as solvents in NMR spectroscopy. Zeochem's standard product range covers the daily requirements of NMR end users. Our products are pre-packed in custom-designed packaging and immediately dispatched when minimum order quantities are met.

Related Products

Spherical Shape

ZEOsphere classical silica-based stationary phases offer excellent separation performance for any type of separation or purification applications.

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Irregular Shape

Irregular shape chromatography silica gels are used as industrial column packing material for the purification of natural products, chemicals and active pharmaceutical ingredients, as well as packing material for flash cartridges and SPE (solid phase extraction).

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Microbeads

Amorphous porous chromatography silica gels in spheroidal shape (microbeads) are used as industrial and analytical column packing material. They perform particularly well as packing material for flash columns.

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NMR Solvents

Zeochem offers a broad range of NMR solvents and deuterium labeled products for routine analytics and research & development. The main application is for use in NMR spectroscopy.

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Deuterium Used as Tracer or Marker

Zeochem offers deuterium oxide in different isotopic qualities, which are used in the tracer and marker fields for food, beverage, agriculture and hydrology industries.

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Custom Solutions

Zeochem's technical service team, engineers and chemists have decades of experience and are here to answer questions, troubleshoot and find solutions to your most challenging problems.